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Function by Other people, including Dickey, has shown that upsized mucin secretion while in the airways performs in Considerably the identical way, involving analogous vesicles (crammed with mucin as an alternative to neurotransmitters) and synaptotagmin and collaborating proteins.
In response to some signal while in the mobile, these granules fuse Together with the mobile membranes to release mucin in to the airways. There, mucin interacts with drinking water and salts to build mucus. If an excessive amount of mucin is unveiled as well rapidly, it could possibly overwhelm the out there h2o. This generates mucus that is definitely much too thick and clogs airways.
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The workforce centered on blocking a protein named synaptotagmin-two, or Syt2. Syt2 is observed on the surface area in the granules that contains mucin. Fusion of these granules With all the cell membrane relies on Syt2 interacting with proteins within the cell membrane.
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